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Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains | Science Translational Medicine
1 day ago
A single-cell transcriptomic atlas with integrated proteomics for the prefrontal cortex of...
Bayesian modeling for analyzing heterogeneous response in preclinical mouse tumor models | Science Translational Medicine
1 day ago
Statistical modeling allows the classification of individual tumor responses and assessment of...
Inhibition of an Alzheimer’s disease–associated form of necroptosis rescues neuronal death in mouse models | Science Translational Medicine
1 day ago
A granulovacuolar degeneration–associated form of necroptosis represents an Alzheimer’s disease–related type of...
Protumoral lipid droplet–loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted | Science Translational Medicine
1 day ago
Protumoral foamy macrophages are associated with poorer survival in humans with glioblastoma...
Engineering CAR-T therapies for autoimmune disease and beyond | Science Translational Medicine
1 day ago
Emerging CAR-T technologies offer transformative potential to address the needs of patients...
A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy | Science Translational Medicine
1 day ago
A fasting-mimicking diet treatment restores renal function in glomerulopathy and provides preliminary...
Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy | Science Translational Medicine
9 days ago
Stromal reprograming by FAK inhibition overcomes RAS-MAPK inhibition resistance and enhances responses...
Characterization of clonal dynamics using duplex sequencing in donor-recipient pairs decades after hematopoietic cell transplantation | Science Translational Medicine
9 days ago
Mutation load and clonal hematopoiesis are similar between donors and recipients, even...
Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy | Science Translational Medicine
9 days ago
Potent lysyl-tRNA synthetase inhibitors advance our understanding of desirable properties for achieving...
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa | Science Translational Medicine
9 days ago
mRNA booster vaccines for SARS-CoV-2 induce circulating virus neutralizing antibodies that may...
SARS-CoV-2 XBB.1.5 mRNA booster vaccination elicits limited mucosal immunity | Science Translational Medicine
9 days ago
COVID-19 mRNA booster vaccines induce limited mucosal immunity.
From blood to mucosa | Science Translational Medicine
9 days ago
Current COVID-19 vaccines induce suboptimal respiratory mucosal immunity even after mRNA boosters...