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Last updated 2 days ago
Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models | Science Translational Medicine
2 days ago
Lysosomal storage disorder mice show bowel transit defects and profound loss of...
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy | Science Translational Medicine
2 days ago
Xenon inhalation modulates microglial responses in mice and is a potential therapeutic...
Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease | Science Translational Medicine
2 days ago
Dysfunctional mitochondrial fusion in intestinal epithelial cells is linked to chronic inflammation...
Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis | Science Translational Medicine
2 days ago
Orthopedia regulates the transcription of melanocortin 4 receptor in hypothalamic neurons, and...
Macrophage-specific in vivo RNA editing promotes phagocytosis and antitumor immunity in mice | Science Translational Medicine
2 days ago
An optimized macrophage-specific transfection strategy supports in vivo CRISPR editing of mRNAs...
A population of c-kit+ IL-17A+ ILC2s in sputum from individuals with severe asthma supports ILC2 to ILC3 trans-differentiation | Science Translational Medicine
2 days ago
c-kit and IL-17A-expressing ILC2s in sputum from individuals with severe asthma exhibit...
Hypoxia-inducible factor 2 regulates alveolar regeneration after repetitive injury in three-dimensional cellular and in vivo models | Science Translational Medicine
9 days ago
Inhibiting hypoxia-inducible factor 2 promotes functional alveolar epithelial repair after recurrent lung...
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination | Science Translational Medicine
9 days ago
Protein kinase C modulation with bryostatin-1 enables innate immune cells in the...
An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations | Science Translational Medicine
9 days ago
An immunogen engineered by computational and structure-based methods activated diverse B cell...
High-frequency epidural electrical stimulation reduces spasticity and facilitates walking recovery in patients with spinal cord injury | Science Translational Medicine
9 days ago
High-frequency epidural electrical stimulation reduces spasticity, enabling protocols to improve recovery in...
Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1-familial platelet disorder | Science Translational Medicine
9 days ago
CD74 signaling drives inflammation and differentiation defects in hematopoietic stem and progenitor...
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance | Science Translational Medicine
9 days ago
Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.