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Last updated 9 days ago

Atlas of the plasma proteome in health and disease in 53,026 adults

9 days ago

A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to...

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

9 days ago

A machine-learning approach enables the quantification of microbial load (microbial cells per...

A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites

9 days ago

Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that...

Proteolethargy is a pathogenic mechanism in chronic disease

9 days ago

Pathogenic signaling leads to reduced mobility of proteins with diverse functions. This...

The single-molecule accessibility landscape of newly replicated mammalian chromatin

9 days ago

By developing a long-read sequencing method to simultaneously map replication status and...

Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration

9 days ago

Intermittent fasting halts hair follicle regeneration by activating communication between adrenal glands...

Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice

9 days ago

Stress induces threat memory generalization in mice by expanding the engram ensemble...

Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation

9 days ago

Intercellular crosstalk between glia-like type I and chemosensory type II cells provides...

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

9 days ago

ApoE2 and ApoE Christchurch variants are defective in LDLR binding, thus reducing...

Configuration of electrical synapses filters sensory information to drive behavioral choices

9 days ago

Sensory information can be differentially processed, enabling similar sensory stimuli to elicit...

Functional genomics of human skeletal development and the patterning of height heritability

9 days ago

A framework for understanding complex-trait genetic uncovers regulatory networks underpinning human height...

The genomic origin of early maize in eastern North America

9 days ago

Ancient maize genomes reveal recurrent northward movements from its domestication center, culminating...